Parkin occurs in a stable, non-covalent, ∼110-kDa complex in brain
نویسندگان
چکیده
منابع مشابه
Parkin occurs in a stable, non-covalent, ∼110-kDa complex in brain
Mutations in the gene for parkin, a 52-kDa E3 ubiquitin ligase, are a major cause of hereditary Parkinson's disease (PD). In vitro studies have identified a large number of parkin-interacting proteins. Whether parkin exists as a monomer or as part of a stable protein complex in vivo is uncertain. Here we demonstrate that endogenous parkin occurs in a stable, non-covalent, approximately 110-kDa ...
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Mutations in a protein designated Parkin were shown to be involved in the pathogenesis of autosomal recessive juvenile parkinsonism. Nothing is known about its regional and subcellular distribution in the mouse. In order to elucidate the Parkin mRNA and protein distribution in the adult mouse, the mouse cDNA was cloned and polyclonal antisera were generated against the N-terminal part of mouse ...
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ژورنال
عنوان ژورنال: European Journal of Neuroscience
سال: 2008
ISSN: 0953-816X,1460-9568
DOI: 10.1111/j.1460-9568.2007.06000.x